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Alzheimer's Disease

News, opinions and meeting coverage in geriatrics.

A photo of a normal brain next to a brain with advanced CTE.

Evidence of CTE Rare in Military Personnel

Limited number of cases preclude causal conclusions

SLEEP over a photo of the Charlotte Convention Center in North Carolina

Unstable Sleep Patterns Linked With Worsening Cognition

Longitudinal data put sleep variability in a negative light

A motion blurred photo of a senior man walking and a young boy running on a city sidewalk.

Walking Speed Helps Predict Future Dementia

Dual decline in gait speed and cognition tied to higher dementia risk

A graphic from the American Heart Association of Life鈥檚 Simple 7.

Even With High Genetic Risk for Alzheimer's, Lifestyle Factors Matter

Midlife scores on Life's Simple 7 tied to dementia incidence across a range of genetic profiles

A computer rendering of a transparent brain with the choroid plexus highlighted.

Alzheimer's, Cognitive Impairment Linked With Choroid Plexus Volume

Blood-CSF barrier may play a role in Alzheimer's pathogenesis

A photo of a senior man eating a hot dog at a country fair.

Brain Aging Markers Tied to Inflammatory Foods

Smaller brain volume seen with diet-driven inflammation

A close up rubber gloved hands collecting cerebrospinal fluid with a vial from a spinal needle

Can Young Cerebrospinal Fluid Boost Cognition?

Brain fluid from young mice improved memory in older ones

FDA APPROVED Lumipulse G 尾-Amyloid Ratio (1-42/1-40) test over a computer rendering of amyloid plaques around neurons.

Early Alzheimer's Test Gets FDA Nod

First in vitro diagnostic to detect amyloid in early disease setting

A close up of a woman鈥檚 hand gnarled by arthritis resting on the head of a cane.

Is Alzheimer's Risk Lower With TNF Inhibitors?

For arthritis patients with cardiovascular disease, the answer may be yes

A photo of a man鈥檚 hand with IV line attached and the vial and packaging of Aduhelm

Medicare Finalizes Limits on Aducanumab Coverage

But decision allows flexibility for some anti-amyloid Alzheimer's drugs

AAN over a photo of the Washington State Convention Center, Seattle, WA.

Memory Enhancer Succeeds in Phase II Alzheimer's Trial

Novel NMDA-targeted drug would expand options for symptomatic treatment

A photo of the vial and packaging of Aduhelm.

Aducanumab Data Finally Published, but Alzheimer's Experts Spot Problems

Questions raised about secondary endpoints

A cross section slice of a brain with Alzheimer鈥檚 disease

COVID Brain Changes Show Parallels With Alzheimer's Disease

Findings may point to potential mechanism for brain fog in people with long COVID

The packaging and vial of Aduhelm over a close up of a Medicare card

Medicare Plans to Restrict Coverage of New Alzheimer's Drug

Proposal would cover aducanumab (Aduhelm) in patients on qualifying clinical trials

An illustration depicting Alzheimer鈥檚 disease with amyloid plaques forming between neurons

Alzheimer's Drugs Race to FDA

After aducanumab, drug companies pivot to use the accelerated approval pathway

A photo of Viagra pills blister pack and packaging.

Can Viagra Prevent Alzheimer's?

Sildenafil shows potential for drug repurposing

The vial and packaging of Aduhelm (aducanumab) over a close up of a man鈥檚 hand with IV attached.

Let Ethics Guide Aducanumab Prescribing, AAN Says

Don't rely on FDA approval alone to make best choices for Alzheimer's patients

An MRI image of a brain with Alzheimer鈥檚 disease.

One Aducanumab Patient, Six Brain Edema Episodes

"Uniquely complicated course" for patient treated with new Alzheimer's drug

I'm a Neurologist With Alzheimer's

How knowledge helps the uncertainty

EASD over an illustration of a person's hand and blood glucose monitor and other icons associated with diabetes.

Healthy Lifestyle Keeps Dementia at Bay in Patients With Diabetes

Maintaining control of risk factors neutralized excess dementia risk

The packaging and blister packs of Ritalin (methylphenidate)

Stimulant Reduces Apathy in Alzheimer's Disease

Twice daily methylphenidate showed modest effect size

A close up of a man's white rubber gloved hand picking up a bullet shell from the floor with tweezers.

Preventing Gun Violence in Patients With Dementia

Gun safety advocate Emmy Betz, MD, MPH, offers advice

A computer rendering of beta-amyloid protein forming plaques and collecting between neurons.

Amyloid Tipping Point Helps Predict Alzheimer's Dementia Onset

Algorithm requires only one PET scan and age

Feared ARNI Effect on Cognition Hasn't Come to Fruition

Neurocognitive protection by sacubitril/valsartan suggested instead by observational study

A computer rendering of a heart cross section with implanted left ventricular assist device

Some Reassurance on Cognition in People With Older LVADs

Will newer devices look even better for neurological outcomes?

A technician prepares blood samples for mass spectrometry

Blood Test Discerns Alzheimer's From Other Dementia With High Accuracy

Plasma p-tau moves another step closer to clinical use

AAIC over a computer rendering of phosphorylation of tau proteins leading to disintegration of microtubuli in a neuron axon

Driving Patterns Pinpoint Early Alzheimer's Disease

Subtle shifts in on-road behavior suggest GPS-based biomarkers may have merit

AAIC over a computer rendering of phosphorylation of tau proteins leading to disintegration of microtubuli in a neuron axon

COVID-19: Persistent Cognitive Effects, Uptick in Alzheimer's Biomarkers

Findings link cognitive impairment and long-lasting anosmia

INVESTIGATIVE ROUNDUP over an image of two people looking at computer screens.

Epic's AI Fail; Controversial Alzheimer's Marketing; No Good COVID Drugs

This past week in healthcare investigations

AAIC over a computer rendering of phosphorylation of tau proteins leading to disintegration of microtubuli in a neuron axon

Aducanumab: What to Know If You Prescribe

Recommendations may change when trial data are published

AAIC over a computer rendering of phosphorylation of tau proteins leading to disintegration of microtubuli in a neuron axon

Better Air, Better Brains

Reducing air pollution tied to lower dementia risk, slower cognitive decline

A stressed looking senior woman next to a bottle of Nuplazid (pimavanserin) capsules.

Staying on Pimavanserin Cut Dementia-Related Psychosis Relapse

However, late-stage trial couldn't separate efficacy in dementia subtypes

A senior woman talks on her smartphone at home.

Phone Calls Spot Early Alzheimer's

Predictive model identified vocal features of dementia patients from everyday speech

The YouTube video thumbnail with Dr. Zubin Damania and Vinay Prasad, MD, MPH, and the words IVERMECTIN& Aducanumab?

Ivermectin and Aducanumab: Do They Work?

ZDoggMD and Vinay Prasad, MD, MPH, analyze the evidence

The vial and packaging of Aduhelm (aducanumab) for injection with blurred prescribing information in the background.

Alzheimer's Aducanumab Prescribing Information Changes

"We as neurologists need a strategy to advise our patients," experts say

A chart showing estrogen levels in a female silhouette from age 25-80

Alzheimer's Biomarkers Tied to Endogenous Estrogen Exposure in Women

Longer reproductive period linked to amyloid, p-tau in cognitively normal older women

A mature person with Down syndrome draws in an activity book.

APOE Gene Influences Alzheimer's Symptoms, Biomarkers in Down Syndrome

Earlier Alzheimer's changes seen in APOE4 carriers

A computer rendering of the release of cytokines.

Two Inflammatory Proteins Linked With Slower Cognitive Decline

Surprise finding ties plasma cytokine levels with Alzheimer's biomarkers and cognition

An FDA APPROVED seal over a photo of prescription bottles on a shelf

The FDA Is Failing the American People

The agency's recent decision to approve aducanumab offers more evidence of a broken system

A microscopy of Neurofibrillary tangles in the Hippocampus of an old person with Alzheimer-related pathology.

Alzheimer's Tau Vaccine Shows Immune Response, Safety

Exploratory, post hoc analyses hint at plasma NfL changes, and in some, slower cognitive decline

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